Search results for "Available drugs"

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Novel Lipid and Polymeric Materials as Delivery Systems for Nucleic Acid Based Drugs

2015

Nucleic acid based drugs (NADBs) are short DNA/RNA molecules that include among others, antisense oligonucleotides, aptamers, small interfering RNAs and micro-interfering RNAs. Despite the different mechanisms of actions, NABDs have the ability to combat the effects of pathological gene expression in many experimental systems. Thus, nowadays, NABDs are considered to have a great therapeutic potential, possibly superior to that of available drugs. Unfortunately, however, the lack of effective delivery systems limits the practical use of NABDs. Due to their hydrophilic nature, NABDs cannot efficiently cross cellular membrane; in addition, they are subjected to fast degradation by cellular and…

Cellular membranePolymersAntisense oligonucleotides aptamers carbon nanotubes exososomes liposomes miRNA polymers siRNAAptamerClinical BiochemistryNanotechnologyAnimals; Humans; Lipids; Nanoparticles; Nanotubes Carbon; Nucleic Acids; Polymers; Drug Delivery SystemsBiologyNanoparticleDrug Delivery SystemsNucleic AcidsAnimalsHumansAvailable drugsPolymerPharmacologyNanotubesNucleic AcidAnimalNanotubes CarbonCarbon chemistryRNALipidLipidsCarbonSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoAntisense oligonucleotidesNucleic acidNanoparticlesHuman
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Novel Immunologic Approaches to Melanoma Treatment

2017

Approaches to treating melanoma have changed radically since the introduction of immunotherapy, and survival figures are now higher than possible with earlier therapies. The immunomodulators currently available mainly block CTLA-4 (cytotoxicT lymphocyte-associated molecule-4) and PD-1 (programed cell death protein 1) translocated to the cell surface, where they inhibit the antitumor immune response. Treatments blocking these molecules are being more widely used. Research now seeks new molecular targets, the best combinations of available drugs, and biomarkers that can identify ideal candidates for each one.

Clinical OncologyHistologybusiness.industrymedicine.medical_treatmentMelanomaCellDermatologyImmunotherapymedicine.diseasePathology and Forensic Medicine03 medical and health sciences0302 clinical medicinemedicine.anatomical_structureImmune system030220 oncology & carcinogenesisImmunologyMolecular targetsCancer researchMedicine030212 general & internal medicineAvailable drugsbusinessActas Dermo-Sifiliográficas (English Edition)
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